摘要：Aging is a complex process. There is evidence to support a positive correlation between aging and functional loss of antioxidants. This study aimed to determine if D-galactose-induced oxidative stress can be limited by the oral administration of Quercetin. Adult male Wistar rats were treated daily for 3 months with subcutaneously injected D-galactose (150 mg/ kg/day). A second group of rats received D-galactose (150 mg/kg/day) with Quercetin (30 mg/kg/day) by oral gavage. Glutathione, malondialdehyde, nitric oxide levels as well as superoxide dismutase activity in rat brain tissue were measured using spectrophotometric analysis. Brain tissues were prepared for a histopathological evaluation. Structural and oxidative damage was induced by D-galactose. In the group administrated with quercetin, glutathione levels and superoxide dismutase activity were significantly higher than those in the untreated group. Additionally, malondialdehyde and nitric oxide levels were inversely proportional to glutathione levels and superoxide dismutase activity. Histopathological structural damage was identified in the brain tissue of D-galactose treated rats. Our results indicated that although D-galactose-induced oxidative stress, quercetin limited oxidative damage caused by Dgalactose in rats.
