摘要：Antioxidant properties of certain β-adrenoceptor blocking agents (β-ABAs) may provide their significant benefit in the therapy of cardiovascular diseases. Considering mentioned, the potential of original β-ABAs, para-alkoxyphenylcarbamic acid esters 6i–6l and 8f–8i with incorporated 4-(4-fluoro- or 3-trifluoromethylphenyl)piperazin-1- -yl fragment, to reduce stable 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•) applying UV/VIS spectrophotometry and to scavenge peroxynitrite ions (ONOO–) using HPLC method, has been in vitro investigated. It has been observed that para-position of attached alkoxy group has appeared to be most suitable for antioxidative efficiency. The increase in lipophilicity in homological series 6i–6l and 8f– 8i could be regarded as important but it has been questionable whether principal factor in terms of capabilities of these esters being effective reductants of DPPH• and the ONOO– scavengers as well. From entire evaluated set, para-methoxy substituted molecule 6i has been able to reduce reference DPPH• most markedly. The in vitro experiments have also revealed the most pronounced ONOO– scavenging potential of para-propoxy substituted compound 8h.
