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  • 标题:Modeling and Analysis of the Cross-talk Regulators Between the AKT and ERK Signaling Pathways
  • 本地全文:下载
  • 作者:Yaman Arkun
  • 期刊名称:IFAC PapersOnLine
  • 印刷版ISSN:2405-8963
  • 出版年度:2019
  • 卷号:52
  • 期号:1
  • 页码:520-525
  • DOI:10.1016/j.ifacol.2019.06.115
  • 语种:English
  • 出版社:Elsevier
  • 摘要:AbstractThe cross-talk between different signal transduction pathways plays a key role in the regulation of cellular functions. This paper models the major feedback loops involved in the cross-talk between AKT and ERK signaling pathways. The developed models can be used to improve our understanding of the complex interactions between two important pathways at the systems level.
  • 关键词:KeywordsCross-talkcellular signalingERK dynamicsAKT pathwaybistabilityfeedback regulationmodelingbifurcation
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