摘要：Persistent and endocrine disrupting organic pollutants pose serious health risks to humans and wildlife dueto their long half-lives, bioaccumulation and toxicity. These compounds have a negative impact on humanhealth and induce a variety of carcinogenic and non-carcinogenic disorders. Extremely low concentrationsof these compounds can induce adverse health effects in human. Efficient analytical methods are alwaysdemanded in order to extract and determine such low concentrations in environmental and biological samples.In the last decade, studies mostly focused on profiling and identification of persistent and endocrine disruptingpollutants in tissues and body fluids using various analytical methods. However, investigation of trace levelpollutants associated with various disorders requires complex analytical protocols. Biological matrix presentsserious challenges in the extraction of these pollutants mainly because of its complexity and inherent limitationsof extraction procedures. We outline advantages and pitfalls of recent extraction approaches. Analysis ofthese compounds is carried out by using gas and liquid chromatography methods coupled with differentdetectors. We have reviewed the current status of advancements in the area of analytical chromatographyand accomplishments and weaknesses have been pointed out. At the end, we encapsulate some healtheffects and clinical correlates of persistent and endocrine disrupting organic pollutants.
