摘要:Soybean is a member of Fabaceae and a species of legume native to east Asia. It is an annual plant that hasbeen used in China for 5000 years as a food and a component of drugs. Soy contains significant amount ofall the essential amino acids for humans and so is a good source of protein. Soy has an important role inimprovement and treatment of some cancers such as colon, prostate and breast. A total of male mice with30-35 g weight were bought from Razi Institute in Iran. At first the samples were kept under adaptationcondition for two weeks and then randomly grouped into 4 experimental sections as: 1-Control group werefeed with soy-free basic diet. 2-Nutrition containing 20% soy diet. 3-Nutrition containing 30% soy diet. 4-Nutrition containing 50% soy diet. At the end of 8 weeks of treatment blood was collected and serum storedfor hormonal analysis. Results were computed with SPSS software and compared with control group. In20% group the level of testosterone has meaningful decrease in comparison with control group, but in 50%group the level of testosterone has meaningful increase. Levels of LH in 30% and 50% groups have ameaningful increase but no significant difference was observed in FSH and weight of testicles. The numberof sperms in all of the treatments have a meaningful decrease. The result of this research indicated that the20, 30 and 50 percent soy diet had negative effect on male reproductive system in mice.