期刊名称：Karbala International Journal of Modern Science
印刷版ISSN：2405-609X
电子版ISSN：2405-609X
出版年度：2018
卷号：4
期号：2
页码：200-206
DOI：10.1016/j.kijoms.2018.01.006
语种：English
出版社：Elsevier
摘要：AbstractA novel series of tri-substituted imidazole derivatives were synthesized according to the well-known Radziszewski reaction. The desired molecules were obtained by a reaction of benzil, ammonium acetate and different derivatives of 1H-pyrazole-4-carbaldehyde. Structures of the synthesized entities were confirmed with the support of modern techniques like elemental analysis (CHN) and spectral analysis (FTIR,1H and13C NMR and LC–MS). All compounds were screened for their biological potency: antibacterial activity using a serial broth dilution method and antioxidant activity using the DPPH method. Antimicrobial activity was performed against Gram-positive bacteria (Staphylococcus aureus,Bacillus subtilis) and Gram-negative bacteria (Escherichia coli,Pseudomonas aeruginosa). The title compounds showed moderate to excellent antimicrobial and antioxidant potency against different bacterial strains and the DPPH radical.Graphical abstractDisplay Omitted
