摘要：BACKGROUND AND AIMS: SEVERAL PUBLISHED STUDIES ON HUMAN AND ANIMAL MODELS SHOWED INCREASED DENSITIES OF NEUROENDOCRINE CELLS (NE)CELLS IN COLONIC MUCOSA OF INFLAMMATORY BOWEL DISEASE ( IBD) COLITIS. THE AIM OF OUR STUDY IS TO DETERMINE THE (NE) CELLS DENSITIES IN COLONIC MUCOSA OF PATIENTS WITH (IBD). METHODS: COLONIC BIOPSIES FROM 18 PATIENTS WITH IBD ( 8 ULCERATIVE COLITIS, 10 CHRON’S DISEASE) AND 16 HEALTHY CONTROLS WERE EVALUATED HISTOPATOLOGIC WITH HEMATOXYLINEOSIN AND IMMUNOHISTOCHEMICAL WITH CHROMOGRANIN A (CGA) AND SYNAPTOHYSIN(SYN) ANTIBODIES. RESULTS: NE CELLS WERE COUNTED ON A TOTAL MEDIAN NUMBER OF 24.1(7,56) CRYPTS FOR CGA, 24(5,57) FOR SYN IN IBD GROUP AND 29 (11,64) CRYPTS FOR CGA AND 29,2(11.52) CRYPTS FOR SYN IN CONTROLS. THE TOTAL DENSITIES/SUBJECT OF NE CELLS WERE SIGNIFICANTLY HIGHER IN IBD GROUP COMPARED TO CONTROLS FOR BOTH CGA AND SYN: 1.45(0.72,2.78) AND 0.86(0.43,1.73) FOR CGA (P= 0,006), 0.89(0.22,1.63) AND 0.63(0.28,1.28) FOR SYN (P=0,025) CONCLUSIONS: OUR STUDY SHOWED AN INCREASED DENSITY OF CGA AND SYN POSITIVE NEC IN PATIENTS WITH IBD.
