摘要:The study investigated the effect of scaffolding and hands-on instructional approaches on seniorsecondary school students achievement and interest in chemistry. The study was carried out in Anambra State,Nigeria. The study was quasi-experimental. The sample size was made up of 195 chemistry students. TheChemistry Achievement Test (CAT) and chemistry interest scale were used for data collection. Means, standarddeviation and Analysis of Covariance (ANCOVA) were used to analyze the data. The findings showed thatstudents who were taught using scaffolding and hands-on instructional approaches had significant achievementcompared to their counterparts taught with conventional method. Scaffolding and hands-on instructionalapproaches increased students interest in chemistry more than the conventional method. There was nosignificant influence of gender on the mean achievement and interest scores of students in chemistry. Finally,there was no significant interaction effect of methods and gender on students achievement and interest inchemistry.