摘要：Severe acute pancreatitis (SAP) is a common acute inflammation in pancreas with a high mortality rate. Recently HMGB1 is reported to be involved in the inflammation of SAP. To investigate the role of HMGB1 A-BOX Protein alleviates liver injury in acute pancreatitis. A total of 84 Wistar rats were randomly divided into the following three groups, mild acute pancreatitis (MAP, n=28), severe acute pancreatitis (SAP, n=28) and sham operation (Control, n=28) groups. After recombinant HMGB1 treatment. The serum HMGB1 concentration were measured by ELISA, and pancreatic sections were stained with hematoxylin and eosin (HE) for histologic analysis and score. The total of 4 scores was the final score of pancreas injury. Serum amylase and lipase levels were measured Liver injury was assessed by measuring the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in serum. In SAP mice model, liver was concurrently injured, and the protein level of HMGB1 was up-regulated in pancreas and serum when compared to the control group. However, ABOX treatment could alleviate the liver injury on some extent. Furthermore, Liver function was restored, reflecting by the downregulation of AST, ALT, and LDH after A-BOX treatment. In conclusion, HMGB1 A-BOX could heal liver injury and possessed the potency for treating ASP in clinical.
