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  • 标题:NOVEL BIOACTIVITIES OF CASSIA NEMOPHILA PODS AGAINST DIABETIC NEPHROPATHY: IN VITRO AND IN VIVO STUDY
  • 本地全文:下载
  • 作者:Gauhar Rehman ; Saba Arshad ; Muhammad Hamayun
  • 期刊名称:Fresenius Environmental Bulletin
  • 印刷版ISSN:1018-4619
  • 出版年度:2019
  • 卷号:28
  • 期号:4
  • 页码:2656-2663
  • 语种:English
  • 出版社:PSP Publishing
  • 摘要:Genetic disorders can actively be treated through wise use of medicinal plants. Plants are natural source that are very cheap to treat life threatening ailments with no side effects. Cassia nemophila from genus Cassia is one of the best examples that can serve as a best alternative to the expensive synthetic drugs. We have planned to investigate the pharmacological properties of ethanolic extract of Cassia nemophila pods (CNPE) against diabetic nephropathy. CNPE at 300µg/ml has significantly (P= 0.05) improved the albumin urea, weight loss and blood glucose in diabetic mice. Moreover, CNPE has stabilized human red blood cells membrane at 2 mg/ml and scavenged the free radicals at 25µg/ml. The results implied the pharmacological importance of CNPE and its effectiveness against antioxidant, anti-inflammatory and anti-diabetic nephropathy. Therefore, CNPE is recommended for further investigation and advanced studies.
  • 关键词:Cassia nemophila;antioxidant;anti-inflammatory;diabetes;nephropathy
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