摘要：The crude (MeOH:CHCl_3) and n-hexane-solu- ble extracts from four brown algae (Phaeophyceae) [Petaloniafascia,Cystoseira crinita,Cystoseirafoe- niculacea, and Halopteris scoparia], one red alga (Rhodophyta) [Jania rubens] and three green algae (Chlorophyta) [Chaetomorpha aerea, Codium frag- ile subsp. fragile, and Ulva compressa] from Turkish coasts (Izmir Bay, Ayvalik and Çanakkale) were assessed in vitro for their acetylcholinesterase (AChE) inhibitory activities at 200, 150, 50, 20 µg/mL test concentration with Ellman's method. The crude extract of P. fascia possessed the highest inhibition (IC_(50) value of 19,22±10,47 µg/mL) against AChE. Galanthamine HBr was used as standard drug that gave against AChE enzyme IC_(50) of 3.44±1.14 µM. In the second stage, the crude, hexane-soluble, chloroform-soluble and water-methanol soluble extracts of the marine algae were observed in vitro against parasitic protozoa (Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma cruzi ve Leishmania infantum). According to results, the most potent protozoal activities were shown by the Khex of C.crinita (IC_(50) value of 10,62 µg/ml)，followed by the Khex of C. fragile subsp. fragHe (IC_(50) value of 11,89 µg/ml). The hekzan-soluble (Khex) and chloroform-soluble (KCH) extracts gave the best results. The marine algae were also tested on MRC-5 cells (human fibroblasts) for by controlling tamoxifen. The extracts of H. scoparla, C. aerea ve C. fragile subsp. fragile showed toxicity.
