摘要：Graphical abstractDisplay OmittedAbstractCoumarin (CMR) is a small molecule with diverse biological functions as anti-tumor,anti-fungal, anticoagulant and antimicrobial activities. CMR is poorly water soluble molecule with low bioavailability. Lipid-based colloidal carriers play an important role in the delivery of hydrophobic compounds. Langmuir technique is an effective method to evaluate interactions between drugs and lipids. In this study, we used 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DPPG), 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE), and 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) lipids. Interfacial characterization was carried out based on surface pressure (π)-area (A) isotherms of pure and mixed films. Topographical analysis was performed using atomic force microscopy. The miscibility of the mixed films was dependent on their composition. The mixed films were stable due to the intermolecular attractive interactions. Our results contribute to the understanding of CMR-lipid interactions aiming to obtain stable colloidal carriers for drug delivery.
关键词：Langmuir films;Langmuir-Blodgett;Coumarin;Phospholipids;Atomic force microscopy
