摘要:AbstractThe search for new antimicrobial agents for the management of infections is of increasing interest because of the intense growing resistance of antibiotics to bacteria. Eighteen medicinal plants’ extracts, these plants belonging to different families were fractionated using different solvents with varying polarity (hexane, chloroform and methanol), with historical use against infections in a primary and secondary screening for activity againstCandida albican, Aspergillus fumigatus, Crytococcus neoformans, Escherichia coli, Pseudomonas aeruginosa,Klebsiella pneumoniae, Vancomycin resistanceenterococcusand Methicillin-resistancestaphylococcus aureusin anin vitroassay. The methanol extract of leaves ofLeptadenia hastata(IC50(µg/mL) = 22.53 (MRS), 11.89 (VRE)) and chloroform extract of seeds ofParkia biglobosa(IC50(µg/mL) = 28.25 (C. neoform.), 85.68 (VRE)) exhibited significant inhibition against the microbes. Though hexane fractions ofP. biglobosaandCrotalaria mucronatashow selective inhibition of IC50(µg/mL) = 28.71 (C. neoform.) and 58.13 (C. alb) respectively. The antimicrobial nature of extracts from the seeds ofP. biglobosa, leaves ofB. ferrugineaandT. preussiwere ascertain in this study for the first time as far as we know. The positive results of these medicinal plants constitute vital reference for on-going phytoanalysis and biological studies.