摘要：AbstractSoy protein isolate (SPI) protein/polymer composite hydrogels (PPCGs) are fabricated in a urea solution of SPI using acrylic acid as monomer, ammonium persulphate (APS) as initiator, andN,N‐methylenebisacrylamide (BIS) and glutaraldehyde (GA) as cross‐linking agents. The scanning electron microscope (SEM) results show that SPI/polyacrylic (PAA) composite hydrogels formed network structure. In particular, in the absence of cross‐linking agent (GA), the network structure of composite hydrogels is also formed by BIS cross‐linking chains of PAA and the hydrophobic interactions between peptides from SPI and chain of PAA. In addition, composite hydrogels have good water absorption and present excellent pH sensitivity. Composite hydrogels adsorb bovine serum albumin (BSA) with higher adsorption capacity. BSA is the control released in pH 7.4 buffers and the accumulative release ratio achieved is 90%. It will be expected that these protein/polymer composite hydrogels could be applied for drug sustained release materials.Soy protein isolate (SPI),a protein with reproducible resource, good biocompatibility, and biodegradability,is employed to fabricate a new kind of SPI/polyacrylic acid (PAA) hydrogel. The networks are formed both in presence and absence of the second cross‐linking agent glutaraldehyde. Hydrogels exhibit the excellent swelling capacity in water. In addition, hydrogels load globular protein BSA and controlled release of macromolecules.
关键词：composite hydrogelscontrolled releasepolyacrylic acidprotein deliverysoy protein isolate
