This paper proposed a new smart home system that is designed based on ZigBee network and STM32F407 microprocessor. The system architecture, the basic circuit diagram and the flowchart of the software system are also provided. This smart home system integrates home appliances, lighting system, entry guard system, smoke sensors, automatic curtains and other equipment by connecting them to a ZigBee network. An STM32F407 MCU is used as the main control microprocessor to implement the interconnection among ZigBee, GPRS and WiFi networks. Users can use the smart home system by operations on a touch screen connecting STM32F407. By using a smart phone or tablet connected to a WiFi or GPRS network, users can also remotely monitor and control all home appliances in the smart home system.