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  • 标题:Analysis of proteomics data: Bayesian alignment of functions
  • 本地全文:下载
  • 作者:Wen Cheng ; Ian L. Dryden ; David B. Hitchcock
  • 期刊名称:Electronic Journal of Statistics
  • 印刷版ISSN:1935-7524
  • 出版年度:2014
  • 卷号:8
  • 期号:2
  • 页码:1734-1741
  • DOI:10.1214/14-EJS900C
  • 语种:English
  • 出版社:Institute of Mathematical Statistics
  • 摘要:A Bayesian approach to function alignment is introduced. A model is proposed in the ambient space, with a Dirichlet prior for the derivative of the warping function and a Gaussian process for the square root velocity function. Posterior inference is carried out via Markov chain Monte Carlo simulation. The methodology is applied to a dataset of mass spectrometry scans. Good alignment is obtained for most of the known proteins, with more uncertainty at either end of each scan.
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