摘要：Fed-batch bioreactors are multiple input, multiple output non-linear systems with a central role in the production of antimicrobials, fine-chemicals and desirable products of pharmaceutical industry, and as such industrial microbial bio-catalytic processes require understanding of the microorganism, the bioreactor, and the set of differential equations that allow the description of the fermentation system. In the present study, we show our preliminary modelling results of growth ofCorynebacterium glutamicumwild type strain ATCC13032 in a single sugar system. The differential equations consider an unstructured model ofC glutamicumto describe the liquid and gas phase, and the results suggest that is possible to model the titers in the liquid and concentrations in the gas phase for the simple sugar system. We anticipate that these results are the basis for furtherC glutamicumfed-batch reactor modelling with other carbon sources, complex mixtures of them, implementation of novel control and optimization structures, and the development of state estimators fromin-situmeasurements.
