出版社：International Medical Journal Management and Indexing System
摘要：Tea (Camellia sinensis) is a rich source of polyphenols called flavonoids, effective antioxidants found throughout the plant kingdom. A group of flavonoids in green tea are known as catechins, which are quickly absorbed into the body and are thought to contribute to some of the potential health benefits of tea. The fresh tea leaves contain four major catechins as colourless water soluble compounds. epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC) and epigallocatechin gallate (EGCG). The aim of present n work is to study antigenotoxic effect of Green tea extract (GTE), against genotoxic damage induced by anticancer drugs Docetaxel and Tamoxifen in cultured human lymphocytes, both in absence and presence of metabolic activation, using duplicate peripheral blood cultures. Metaphase plates so obtained were used for Sister chromatid exchange (SCEs) analysis and calculation of Replication index. We found that the genotoxicity induced by Tamoxifen and Docetaxel, separately can be countered with Green tea extract (GTE) doses.
