摘要:The standard definition of the key performance indicators for the manufacturing operations management level could not resist the incoming challenges and models of the 4thindustrial revolution, which currently relies on the paradigms abiding by the cyber-physical system of systems vision. By means of a brief survey of the current trends, a set of recommendations are provided in order to open discussions for the foreseen evolutions of the ISO 22400 standard. A focus is made on the role of the humans in their increasingly closer collaboration with the pervasive autonomous intelligent entities in the context of a human-centered manufacturing. It is contended that there is still some room for a review of the definitions of the performance indicators and their structure that should aim to reflect human and intelligent automation aspects in an integrated framework.