摘要：Graphical abstractDisplay OmittedAbstractBenzimidazole derivatives1–20were synthesized and evaluated for antiglycation and antioxidant potentials. Among the series some analogs showed antiglycating potential ranging in between 182.30 ± 1.20 and 473.51 ± 2.17 when compared with standard rutin (IC50value 295.09 ± 1.04 µM) and for antioxidant potential ranging between 22.42 ± 0.26 and 82.30 ± 1.33 when compare with standard Propyl gallate (IC50value 29.20 ± 1.25). Compound2,6,10and19showed potent antioxidant and antiglycation inhibitory potentials. Compounds7,11,13, 15and20showed moderate antiglycating potential with IC50values 473.51 ± 2.17, 325.20 ± 1.70, 440.0 ± 3.60, 370.60 ± 2.80 and 415.20 ± 3.20 μM, and these compounds also showed excellent antioxidant potential with IC50values 73.51 ± 1.17, 45.63 ± 0.92, 82.30 ± 1.33, 75.41 ± 1.51, 40.60 ± 0.80 and 64.92 ± 1.41 μM respectively. The remaining compounds1,3,4,5,8,9,12,14,16,17and18were found inactive.
