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  • 标题:Identification of bioactive compounds in leaf extract of Avicennia alba by GC-MS analysis and evaluation of its in-vitro anticancer potential against MCF7 and HeLa cell lines
  • 本地全文:下载
  • 作者:G. Eswaraiah ; K. Abraham Peele ; S. Krupanidhi
  • 期刊名称:Journal of King Saud University - Science
  • 印刷版ISSN:1018-3647
  • 出版年度:2020
  • 卷号:32
  • 期号:1
  • 页码:740-744
  • DOI:10.1016/j.jksus.2018.12.010
  • 语种:English
  • 出版社:Elsevier
  • 摘要:AbstractThe current study focused on GC-MS analysis for identification of bioactive compounds in leaf extract of mangrove plant,Avicennia albaand the leaf extract ofAvicennia albawas tested for cytotoxicity against MCF 7 and HeLa cell lines. The spectral properties (GC-MS) of each separated compound were determined and found the different compounds namely terpenoids, di-terpene alcohols, tri-terpenes and phenolic compounds. GC-MS analysis proved that the leaf extract ofAvicennia albacontain a high content of phenolic compounds. The methanol extract showed potent cytotoxicity against Human breastadeno carcinoma (MCF7) and HeLa cell lines, the viability of cancerous cells is reduced to 44.68% for MCF 7 and 35.89% for HeLa cells. The high anticancer activity was found against HeLa cell lines than MCF 7 cell lines.
  • 关键词:Anticancer;HeLa cells;MCF 7 cells;MTT assay;GC-MS
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