标题：One-pot, simple and efficient synthesis of novel bioactive 4-aryl-1,2-dihydro-6-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-oxopyridin-3-carbonitriles via multi-component approach
摘要：Graphical abstractQuantitative multicomponent cyclocondensation of 3-acetyl-4-hydroxycoumarine with ethyl cyanoacetate and aryldehydes has been carried out in ammonium acetate, at reflux.Display OmittedAbstractQuantitative multicomponent cyclocondensation of 3-acetyl-4-hydroxycoumarine with ethyl cyanoacetate and aryldehydes has been carried out in ammonium acetate, at reflux. The optimization details of the developed novel protocol are recorded. The structure of newly synthesized compounds have been characterized by spectroscopic data (elemental analysis, IR and1H NMR spectroscopic studied). Antimicrobial properties of the novel coumarins derivatives3are investigated. The acetylcholinesterase inhibition activity (AChEI) was tested for all compounds, and the3bshows the highest AChEI activity with 48.25% of inhibition.
关键词：Multicomponent reaction;4-Hydroxycoumarin;Ethyl cyanoacetate;Antibacterial and acetylcholinesterase inhibition activities
