摘要：In this study, it wasaimed to determine the effects of melatonin application on lipid profile in streptozotocin-induced diabetic rats. Animals in control group were not anytreatment. Melatonin group animals received 50 mg/kg melatoninintraperitoneally in daily for eight weeks. Diabetes was induced bysubcutaneous injections of streptozotocin at dose of 40 mg/kg for two days as asingle dose per day in diabetes group animals. Animals in Diabetes+Melatoningroup were made diabetic by streptozotocinin the same way and then these animals received 50 mg/kg melatoninintraperitoneally in daily for eight weeks. In blood samples taken from all animals, TNF-α,triglyceride, total cholesterol, LDL and HDL were determined. In diabetesgroup, TNF-α level were high (p<0.05). The changes in TNF-α level withmelatonin application to diabetic rats were important (p<0.05). In diabeticrats, triglyceride and LDL levels were found to be enhanced compared to controlgroup (p<0.05), HDL level was significantly low (p<0.05), while thechange in total cholesterol level was not important. With the melatoninapplication to diabetic rats, HDL level was found to be higher (p<0.05) andLDL level was lower than diabetes group (p<0.05). It was concluded that theadministration of melatonin to streptozotocin-induced diabetic rats may have positive effects on lipid profile.
