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  • 标题:Determination of HIF1Ars11549465 Polymorphism in Elite Skiers
  • 本地全文:下载
  • 作者:Ömer KAYNAR ; Fatih BİLİCİ ; Korkut ULUCAN
  • 期刊名称:Turkish Journal of Sport and Exercise
  • 印刷版ISSN:2147-5652
  • 出版年度:2019
  • 卷号:21
  • 期号:2
  • 页码:328-331
  • DOI:10.15314/tsed.544566
  • 语种:English
  • 摘要:ABSTRACTStudies in sport genetics have increasednowadays and the identification of genotype and allelic distributions ofcandidate genes in different athletes has provided important information tosports scientists. One of the candidate genes studied in sports genetics is thehypoxia-inducible factor 1-alpha (HIF1A) gene, which is associated with theendurance phenotype. In our study, we aimed to determine the genotypic andallelic distribution of HIF1Ars11549465 polymorphism in Turkish Elite Ski Runners. 34 (23 male, 11 female)athletes were included in the study, and 1 cc of blood samples taken forroutine analysis after the approval of the ethics committee was used for DNAisolation. The commercial kit was used for DNA isolation and genotyping wasperformed by Real-time PCR method. The number and percentage of CC, CT and TTgenotypes of the HIF1A rs11549465 polymorphism were 24 (72.72%), 8 (24.24%) and1 (3.03), respectively. In male skiers CC, CT and TT genotype numbers andpercentages were determined as 17 (55.51%), 4 (12.12%) and 1 (3.03%)respectively. In female, CC and TT genotypes were determined as 7 (21.21%)and 4 (12.12%). We detected noTT genotype in female athletes. When we look at allel numbers, C allele wasdetermined as 56 (84.84%) and T allele was determined as 10 (15.15%). This isthe first study on HIF1A rs11549465polymorphism on Turkish elite ski runners. The higher prevalence of CC genotypeand C allele in the athlete group is similar to the previous studies ondifferent groups of athletes. We believe that this study will be an importantreference for further studies.
  • 关键词:Sport genetics;cross-country;athletic performance
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