摘要：AbstractObjectiveThe study aims at discussing the clinical efficacy of tranexamic acid in knee arthroplasty and its effects on erythrocyte, ALT (alanine aminotransferase), AST (aspartate aminotransferase) and FDP (fibrinogen degradation product) after the operation.MethodTotally, 94 patients who underwent knee arthroplasty in our hospital from June 2015 to June 2017 were randomly divided into the control group and the observation group, with 47 patients, respectively. The patients in the observation group were given tranexamic acid at a dose of 15 mg/kg dissolved in 100 mL normal saline before knee replacement, while those in the control group were given 100 mL normal saline. The dominant blood loss, recessive blood loss, total blood loss, intraoperative blood loss and the drainage, blood transfusion and blood transfusion rate 24 h in postoperative were counted and observed in both groups, and then the differences of HCT (hematocrit), Hb (hemoglobin), ALT, AST and FDP before and 4d after the operation in two groups were compared, to research and analyze the clinical efficacy of tranexamic acid in knee arthroplasty and its effects on erythrocyte, ALT, AST and FDP after the operation.ResultsFirstly, the total blood loss, dominant blood loss, recessive blood loss, intraoperative blood loss, postoperative blood flow, blood transfusion volume and blood transfusion rate in the observation group were lower than those in the control group (P < 0.01). Secondly, the Hb and HCT of the observation group were significantly lower than those of the control group (P < 0.01). Thirdly, ALT, AST and FDP in the two groups were higher than those before operation (P < 0.01). There was no significant difference in ALT, AST and FDP between the observation group and the control group (P > 0.05).ConclusionThe application of tranexamic acid before knee arthroplasty can reduce intraoperative and postoperative blood loss, and do not affect the coagulation function and liver function of patients, and has high drug safety.
