摘要：SummaryThe phenomenon of protein misfolding and aggregation is associated with a wide range of neurodegenerative conditions that cause progressive loss of function in specific regions of the human brain. To understand the causes of the selective cell and tissue vulnerability to the formation of these deposits, we analyzed the ability of different cell and tissue types to respond, in the absence of disease, to the presence of high levels of aggregation-prone proteins. By performing a transcriptional analysis, we found that the protein homeostasis system that regulates protein aggregation is weaker in neurons than in other cell types and in brain tissues than in other body tissues. These results suggest that the intrinsic level of regulation of protein aggregation in the healthy state is correlated with the selective vulnerability of cells and tissues to protein misfolding diseases.Graphical AbstractDisplay OmittedHighlights•A branch of the protein homeostasis system regulates protein aggregation•This system is weaker in brain tissues than in other body tissues•This system is weaker in Braak regions than in other brain regions•This system is weaker in neurons than in other brain cell typesMolecular Physiology; Neuroscience; Transcriptomics
