摘要：The levels of 17 congeners of Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in human gallbladder tissue and gallbladder stone samples gathered from patients of the “Jordan university hospital” in the period between February 2016 and April 2016, were analyzed. All samples were extracted, cleaned-up, and analyzed using GC-EI/MS. The total mean concentration of dioxins/furans in gallbladder tissues and stone samples were 1.62 gg/kg and 2.30 gg/kg, respectively. In all samples most of diox- in/furans congeners were not detected. Octachlo- rodibenzo-p-dioxin was the most abundant congener with average concentrations of 1.19 gg/kg in gallbladder tissue samples and of 1.64 gg/kg in gallbladder stone samples. The TEQ values for PCDDs/Fs in all samples were found in the range of 0.40 to 124.9 ng TEQ/kg for gallbladder tissue samples and 15.7 - 135.9 ng TEQ/kg for gallbladder stone samples. The distribution coefficient for diox- ins/furans were calculated between gallbladder stones and gallbladder tissue in each sample. The distribution coefficients, (Kd = Csto n e/Ct is s u e) for dioxins/ furans were found in the range 0.88 to 2.06. The variations in Kd depend mainly on the type of gallbladder stone and on the fat content of the gallbladder tissue (obesity) of the patient. The results of this study show that both gallbladder stones and gallbladder tissues can be used as a good indicator for body pollution especially if the stone was of pure cholesterol type. The concentrations we found in this study are much higher than what Muto [29] found, nevertheless there was no deaths among the donors of the 39 samples in our study. It is also attention drawing that the congeners 1.2.3.6.7.8- hexachlorodibenzino-p-dioxin and 1.2.3.4.6.7.8- heptaclorodibenzo-p-dioxin are present at high frequency, numerically 97.4% and 100% respectively.
