摘要：Recently, the use of new rare earth metals such as nanosize lanthanum oxide has extensively increased, being used in optical glasses, batteries and alloys-：-Nonetheless, the risk of toxicity of lanthanum oxide nanoparticles (La2 0 3NPs) has not been studied before. In this experiment, we have determined the toxic and inflammatory response of La2 0 3NPs on BEAS-2B bronchial epithelial cells and A549 lung cancer cells for 24 hours. The BEAS-2B and A549 cells were exposed to La2 0 3NPs (0, 1, 5, 20, 40, 100 g/ml) for 24 hours. In this work, a comprehensive study on the toxicity of La20 3NPs by observing its effect on the morphology, viability, m ortality and apoptosis in both cells was studied. La20 3NPs induced oxidative stress, interleukin (IL-6 and IL-8) and TNF-a in a dose-dependent manner in both cells but, significant effect on cell toxicity at higher concentrations was noticed. However, La2 0 3NPs were able to elicit multiple stress responses, secretion of proinflammatory cytokines in BEAS-2B and A549 cells. DNA damage was significant, as evaluated by single cell gel electrophoresis, and dose-dependent in both cells. Overall, our findings support La2 0 3NPs as a potentially toxic nanoparticle at the cellular level, and needs careful assessment before being used in medical and industrial sectors.
