摘要:Antibiotics are commonly used tofight against bacterial infections, but bacteria have already been resistant to almost all antibiotics due to abuse of antibiotics. Triazole derived compounds possess chemotherapeutic effects including potential antibacterial activities against drug-sensitive as well as drug-resistant pathogens. We have designed and synthesized a number of triazole alcohol-based antifungals by incorporating N-benzylpiperazine carbodithioate moiety into the phamacophoric framework of fluconazole. In vitro bioassays against fluconazole-susceptible and fluconazole- susceptible dose-dependent Candida species revealed that all compounds had potent activity against C. albicans, C. glabrata, C. parapsilosis, C. krusei, and C. tropicalis, with MIC values <3 g/mL.