期刊名称：Walailak Journal of Science and Technology (WJST)
印刷版ISSN：2228-835X
出版年度：2018
卷号：15
期号：8
页码：569-578
语种：English
出版社：Institute of Research and Development, Walailak University.
摘要：Orgnophosphorous (chyloryrifos) has been widely used for pest control. It is considered to be functionally irreversible inhibitor of cholinesterase (ChE), since the time necessary to liberate the enzyme from inhibition may be in excess of time required for the synthesis of new ChE. This study was designed to investigate the effects of total phenolic content, total antioxidant capacity and free radical scavenging activities in cell free system present in Thunbergia laurifolia (Linn.) (TL) and further examined for their ability against chloripyrifos induced ChE dysfunction in vitro (blood and brain of mice) studies. The results showed that TL has the highest phenolic content, which is significant positive correlation with its antioxidant activity (R2=0.99). Besides, the fifty percent of inhibitory concentration of TL on scavenging free radical activities (IC50) for hydroxyl, superoxide and hydrogen peroxide radical in cell free system were 1.47±0.02, 2.23±0.08 and 1.66±0.09 mg/mL, respectively. We found TL showed a potential inhibition of chloripyrifos-induced ChE dysfunction in a concentration dependent manner. These data suggest that TL exhibits an anti-oxidant and at least in part neuroprotective properties against chloripyrifos-induced ChE alteration. We strongly believe that these antioxidant constituents are prospective novel nutriceuticals.DownloadsDownload data is not yet available.Author BiographyJitbanjong TANGPONG, Division of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161SCHOOL OF ALLIED HEALTH SCIENCES AND PUBLIC HEALTHReferencesTC Marrs. Organophosphate poisoning. Pharmacol. Therapeut. 1993; 58, 51-66.
