标题：Prenatal and postnatal exposures to ambient air pollutants associated with allergies and airway diseases in childhood: A retrospective observational study
摘要：Graphical abstractDisplay OmittedHighlights•We surveyed 3177 preschoolers who did not change residences after birth.•We studied associations of early exposures to NO2, SO2, PM10with airway diseases.•Prenatal and Postnatal exposures to NO2were associated with airway diseases.•Associations of NO2were generally stronger than in the early than later trimesters.AbstractIt’s inconsistent about associations of early exposures to outdoor air pollutants with allergies and airway diseases in childhood. Here, we investigated associations of prenatal and postnatal exposures to outdoor nitrogen dioxide (NO2), sulphur dioxide (SO2), and PM10(particulate matter with an aerodynamic diameter ≤ 10 μm) with asthma, wheeze, hay fever, rhinitis, pneumonia, and eczema in childhood. We surveyed 3,177 preschoolers who never change residences since birth in Shanghai, China. Parents reported information regarding children’s health status. Daily-averaged concentrations of these pollutants in the children’s gestation and in the first year of lifetime for district where children lived were collected by Shanghai Environmental Monitoring Center. After adjusting for covariates, exposures to higher level of NO2during different trimesters of gestation and of the first year of lifetime had significant associations with the increased odds of asthma, hay fever, rhinitis, pneumonia, and eczema in childhood. Associations of NO2exposures in the early trimesters of gestation and of the first year of lifetime with pneumonia were stronger than in the later trimesters, whereas associations of NO2exposures in the early trimesters with hay fever and eczema were weaker than in the later trimesters. Our results indicated that prenatal and postnatal exposures to outdoor NO2could be risk factors for allergies and airway diseases in childhood. Both dose and duration were related with the influence degree of early NO2exposure on childhood allergies and airway diseases.
关键词：Asthma;Allergic rhinitis;Eczema;Ambient air pollution;Childhood
