摘要：Graphical abstractDisplay OmittedHighlights•Weather during critical windows in pregnancy may lead to lower term birthweight.•These critical windows appear to differ between male and female infants.•Temperature variability, not just mean temperature, may impact term birthweight.•Even apart from temperature, mean humidity may affect term birthweight.AbstractBackgroundHeat stress during pregnancy may limit fetal growth, with ramifications throughout the life course. However, critical exposure windows are unknown, and effects of meteorological variability have not been investigated.ObjectivesWe aimed to identify sensitive windows for the associations of mean and variability of temperature and humidity with term birthweight.MethodsWe analyzed data from two French mother–child cohorts, EDEN and PELAGIE (n = 4771), recruited in 2002–2006. Temperature exposure was assessed using a satellite-based model with daily 1-km2resolution, and relative humidity exposure data were obtained from Météo France monitors. Distributed lag models were constructed using weekly means and standard deviation (SD, to quantify variability) from the first 37 gestational weeks. Analyses were then stratified by sex. Results for each exposure were adjusted for the other exposures, gestational age at birth, season and year of conception, cohort and recruitment center, and individual confounders.ResultsThere was no evidence of association between term birthweight and mean temperature. We identified a critical window in weeks 6–20 for temperature variability (cumulative change in term birthweight of −54.2 g [95% CI: −102, −6
关键词：Distributed lag models;Critical windows;Temperature;Humidity;Birthweight;Weather variability
