摘要：SummaryBivalve mollusks are economically important invertebrates that exhibit marked diversity in benthic lifestyle and provide valuable resources for understanding the molecular basis of adaptation to benthic life. In this report, we present a high-quality, chromosome-anchored reference genome of the Venus clam,Cyclina sinensis. The chromosome-level genome was assembled by Pacific Bioscience single-molecule real-time sequencing, Illumina paired-end sequencing, 10× Genomics, and high-throughput chromosome conformation capture technologies. The final genome assembly ofC. sinensisis 903.2 Mb in size, with a contig N50 size of 2.6 Mb and a scaffold N50 size of 46.5 Mb. Enrichment analyses of significantly expanded and positively selected genes suggested evolutionary adaptation of this clam to buried life. In addition, a change in shell color represents another mechanism of adaptation to burial in sediment. The high-quality genome generated in this work provides a valuable resource for investigating the molecular mechanisms of adaptation to buried lifestyle.Graphical AbstractDisplay OmittedHighlights•A chromosome-level assembly for clam genome is provided•The evolutionary order of bivalve adductor muscle is from double to single•The work suggests evolutionary adaptations to a buried lifestyle•Change of shell color represents another mechanism of adaptation to burial in sedimentBiological Sciences; Genomics; Genomic Analysis; Omics
