摘要：SummaryAn ODE model integrating metabolic mechanisms with clinical data reveals an Ohm's law governing lifetime body mass dynamics, where fat and lean tissues are analogous to a parallel nonlinear capacitor and resistor, respectively. The law unexpectedly decouples weight stability (a cell-autonomous property of adipocytes) and weight change (a parabolic trajectory governed by Ohm's law). In middle age, insulin resistance causes fat accumulation to avoid excessive body shrinkage in old age. Moderate middle-age spread is thus natural, not an anomaly caused by hypothalamic defects, as proposed by lipostatic theory. These discoveries provide valuable insights into health care practices such as weight control and health assessment, explain certain observed phenomena, make testable predictions, and may help to resolve major conundrums in the field. The ODE model, which is more comprehensive than Ohm's law, is useful to study metabolism at the detailed microscopic levels.Graphical AbstractDisplay OmittedHighlights•Paradigm shift from lipostatic set-point to leanocentric locking-point•Fat mass homeostasis is a cell-autonomous property of adipocytes•Fat mass change is governed by metabolic Ohm's law•Peripheral insulin resistance is crucial for long-term body protectionBiological Sciences; Endocrinology; Mathematical Biosciences
