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  • 标题:Current Status of COVID-19 Therapies and Drug Repositioning Applications
  • 本地全文:下载
  • 作者:Ozlem Altay ; Elyas Mohammadi ; Simon Lam
  • 期刊名称:iScience
  • 印刷版ISSN:2589-0042
  • 出版年度:2020
  • 卷号:23
  • 期号:7
  • 页码:1-12
  • DOI:10.1016/j.isci.2020.101303
  • 语种:English
  • 出版社:Elsevier
  • 摘要:The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples ofin silicostudies of drug development efforts against SARS-CoV-2.Health Sciences; Medicine
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