摘要：SummaryHistone deacetylase 9 (HDAC9) has recently been demonstrated as a key regulator of vascular smooth muscle cell (VSMC) phenotype and is associated with abdominal aortic calcification, myocardial infarction, and ischemic stroke. It is uncertain whether HDAC9 is also implicated in other VSMC-driven diseases. Our objective was to assess associations between abdominal aortic calcification-associated genetic variation inHDAC9and VSMC-associated phenotypes. In this prospective population study of 335,146 adults enrolled in the UK Biobank, the abdominal aortic calcification-associated risk allele of a genetic variant inHDAC9was associated with increased risk of systolic hypertension, non-ST segment elevation myocardial infarction, and ischemic stroke. There was a suggestive protective association with kidney disease outcomes that did not reach experiment-wise significance. These genetic results lend further support for HDAC9 as a potential therapeutic target for arterial stenotic and calcific disease.Graphical AbstractDisplay OmittedHighlights•AAC-associated variation inHDAC9was associated with hypertension, STEMI, and stroke•A suggestive protective association with kidney function was not significant•HDAC9 could be explored as a therapeutic target for arterial calcific diseaseMedical Specialty; Clinical Finding; Genomics
