摘要：AbstractThis work aimed at evaluating the antihypolipidaemic potential of oil extracted fromIlisha Africanaon rats. The oil was extracted using a soxlhet device and underwent chemical analysis prior toin vivoassays. Twenty four femaleWistaradult rats were randomly divided into four groups of 6 rats each. During a three-week experiment, group 1 was fed with standard laboratory diet (SLD); group 2 received SLD supplemented with cooked egg yolk (5 g/day/rat);group 3 was fed with SLD supplemented withI. Africanaoil (1 g/day/kg of body mass) andgroup 4 was fed with SLD supplemented with cooked egg yolk andI. Africanaoil. Liver, lung, kidney, adipose tissues and heart were later removed, weighted and analyzed. Some bloodbiochemical parameters were also measured. Results showed thatI. Africanaoil is of good quality. Hyperlipidemic diet significantly (p ˂ 0.05) increased cholesterolemia, triglyceridemia, glycemia and proteinemia in group 2 compared to other groups. Supplementation with the fish oil significantly (p ˂ 0.05) decreased total-cholesterol, LDL-cholesterol, triglyceride, glycemia, proteinemia and increased levels of HDL-cholesterolin group 3 compared to group 2 and 4.I. Africanaoil reduced cholesterolemia, triglyceridemia, glycemia and proteinemia in group 4 compared to group 2. This study shows thatI. Africanaoil can be used in prevention of hyperlipidemia.
