摘要：SummaryFlexible sensors are essential for advancing implantable and wearable bioelectronics toward monitoring chemical signals within and on the body. Developing biosensors for monitoring multiple neurotransmitters in real time represents a keyin vivoapplication that will increase understanding of information encoded in brain neurochemical fluxes. Here, arrays of devices having multiple In2O3nanoribbon field-effect transistors (FETs) were fabricated on 1.4-μm-thick polyethylene terephthalate (PET) substrates using shadow mask patterning techniques. Thin PET-FET devices withstood crumpling and bending such that stable transistor performance with high mobility was maintained over >100 bending cycles. Real-time detection of the small-molecule neurotransmitters serotonin and dopamine was achieved by immobilizing recently identified high-affinity nucleic-acid aptamers on individual In2O3nanoribbon devices. Limits of detection were 10 fM for serotonin and dopamine with detection ranges spanning eight orders of magnitude. Simultaneous sensing of temperature, pH, serotonin, and dopamine enabled integration of physiological and neurochemical data from individual bioelectronic devices.Graphical AbstractDisplay OmittedHighlights•We fabricated flexible In2O3nanoribbon transistors using cleanroom-free processes•Flexible In2O3transistors withstood crumpling and bending with stable performance•Flexible aptamer biosensors detect neurotransmitters in real time•Multiplexed sensors monitor temperature, pH, serotonin, and dopamine simultaneouslyNanoscience; Bioelectronics; Nanotechnology Fabrication
