摘要：SummaryCarbon monoxide (CO) plays an important role in the regulation of a variety of physiological processes and thus is regarded as a promising pharmaceutical agent. Nevertheless, therapeutic applications of CO are severely hampered by the difficulty of the delivery of controlled amounts of CO to biological targets. To address this deficiency, we present a spatiotemporally controllable CO-releasing platform (designated as Neu-MnO2/Fla) for synergistic anti-inflammation. With the assistance of neutrophil membrane coating, Neu-MnO2/Fla can target to inflammatory sites. Subsequently, excess H2O2at the inflamed tissues can be decomposed into oxygen because of MnO2as nanozymes possessing catalase (CAT) activity, which not only relieves oxidative stress but also achievesin siturapid photo-induced CO release. Thein vitroandin vivoresults indicate our CO-releasing platform exhibits a strong synergistic anti-inflammatory effect. Our work will shed light on targeted CO release to avoid side effects of therapeutic applications of CO.Graphical AbstractDisplay OmittedHighlights•The Neu-MnO2/Fla was successfully constructed•Neu-MnO2/Fla can deliver CO to inflammatory sites in a safe and effective way•Synergistic anti-inflammatory effects were achieved by combining MnO2and CO•The Neu-MnO2/Fla reduced the level of ROS and pro-inflammatory cytokinesChemistry; Biochemistry; Nanotechnology
