摘要：AbstractCarbon tetrachloride (CCl4) is a Potential nephrotoxin that causes severe and prolonged chemical toxicity. Investigations have been accomplished on numerous species of genusArtemisia, but the plantArtemisia brevifoliahas hardly been used in this respect. The present study was considered to ascertain the effects of “Artemisia brevifoliaplant extract” against CCl4prompted nephrotoxicity in male albino rats. Forty-eight male albino rats were allocated into eight groups containing 6 rats in each. Group I was the control group. Group II was given dimethyl sulfoxide (DMSO) (1 ml/kg) orally. Group III was treated with dissolved CCl4in olive oil (1 ml/kg). Group IV was given CCl4 + Silymarine. Group V and VI were administered withArtemisia brevifoliaextract (150 and 300 mg/kg respectively) + CCl4. Group VII and VIII were provided with only 150 and 300 mg/kg extract ofArtemisia brevifoliarespectively. Results displayed that CCl4administration significantly (p < 0.05) reduced the activity of antioxidant enzymes like catalase (CAT), peroxidase (POD), Superoxide dismutase (SOD), glutathione (GSH), glutathione reductase (GSR), glutathione-S-transferase (GST), albumin, creatinine clearance and Comet parameters (head length, % in head) while increased the level of thiobarbituric acid reactive substances (TBARS), hydrogen peroxide (H2O2), urea, creatinine, urobilinogen, urinary proteins and comet parameters (number of comets, tail length, comet length, tail moment, % in tail). The administration ofArtemisia brevifoliasignificantly (p < 0.05) improved the histopathology of renal tissues. The results revealed thatArtemisia brevifoliahas protective consequences against CCl4induced kidney damage.
