摘要：The effect of crude fatty acid extract of Streptomyces sps isolated from soil on the biofilm formation by Candida albicans MTCC 3017 was investigated. Totally, 25 Streptomyces sps were isolated and identified from the soil samples collected at Nilgiris hills. All the isolates were subjected to hydrogen peroxide assay to identify fatty acid production. Crude fatty acid extracts of all the positive isolates were analyzed for inhibition of biofilm formed by Candida albicans. The extracts of five isolates AP1, AP8, AP9, AP11 and AP23 showed inhibition percentage of 80.56%, 93.25%, 79.53%, 85.39% and 73.29% at 50 µg/ml. Furthermore the -galactosidase activity of extracts indicated capability of inhibiting the production of enzymes and reducing the hyphal growth of C. albicans. This study suggests that the crude fatty acid extracts of Streptomyces sps may be useful in preventing biofilm formation by the pathogen.
