摘要：Chlordecone is an organochloride insecticide mainly used for the control of agricultural pests. The genotoxicity of chlordecone was evaluated through micronucleus test in peripheral erythrocytes of Etroplus maculatus. Chlordecone at sublethal concentration (3.5µg/ l) was exposed to fish for 24, 72 and 96 h durations along with the control groups. The results showed that in vivo chlordecone exposure significantly increase the incidence of micronucleus formation in erythrocytes of fish. In the control groups, no nuclear abnormalities were observed, whereas in chlordecone-exposed groups showed nuclear aberrations such as formation of micronucleus together with blebbed, notched, lobed and irregular nuclei. The changes were found to be positively correlated to the duration of exposure. The present data clearly demonstrated that chlordecone is genotoxic at sublethal concentration in cichlid fish, Etroplus maculatus.
