标题：Effect of Fluoride Exposure on Key Enzymes Activity of Protein - Carbohydrate Metabolism in Gills of Fresh Water Fish Tilapia mossambica, Keenjhar Lake, Thatta, Sindh, Pakistan
期刊名称：International Research Journal of Environmental Sciences
电子版ISSN：2319-1414
出版年度：2013
卷号：2
期号：8
页码：24-27
语种：English
出版社：International Science Community Association
摘要：The effect of fluoride on the activity of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) in gills of fresh water fish Tilapia mossambica, collected from Keenjhar Lake, Thatta, Sindh, Pakistan at sub-lethal concentration of fluoride was measured. Fluoride is a very common non-metallic trace element found in earths crust. It is abundant in our environment but is rarely found in elementary state in nature. Fluoride is known as an inhibitor of various enzymes like lipases, phosphatases and esterases. It disrupts fatty acid oxidation and also inhibits the enzyme activity of acyl-Co-A synthetase, involved in lipid metabolism. Results showed that enzyme activities were significantly altered upon exposure to fluoride due to which protein-carbohydrate metabolism was disturb. Changes in three biomarkers, key enzymes of protein-carbohydrate were related to metabolism of fish at sub-lethal concentration of fluoride. The carbohydrate concentration initially increases and later decreases with the time while a significant depletion of total protein and lipids in gills tissue were observed (p 0.001). It was concluded that fluoride produce toxic effect on physiology of fish gill, which may be associated with increased ionic permeability to gill surface.
