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  • 标题:A new sulphur containing heterocycles having azo linkage: Synthesis, structural characterization and biological evaluation
  • 本地全文:下载
  • 作者:Mallikarjuna Niluvanji Matada ; Keshavayya Jathi ; Maliyappa M. Rangappa
  • 期刊名称:Journal of King Saud University - Science
  • 印刷版ISSN:1018-3647
  • 出版年度:2020
  • 卷号:32
  • 期号:8
  • 页码:3313-3320
  • DOI:10.1016/j.jksus.2020.09.016
  • 语种:English
  • 出版社:Elsevier
  • 摘要:AbstractThe present study aims the development of new S-heterocyclic azo dyes synthesized from 1, 3-benzothiazole-2-thiol with various amines by diazo-coupling method and their structures are established by physico-chemical techniques. The target molecules were screened for antimicrobial, antitubercular, anticancer, and molecular docking studies. These compounds have shown appreciable inhibitory effect against studied microbial strains. Thein silicomolecular docking study exposed the significant interaction properties of the azo compounds against target receptor RpsA and showed an appreciable binding affinity of −4.3 to −5.5 kcal/mol.
  • 关键词:Benzothiazole;Diazotization;Azo dyes;Biological activity
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