摘要：Allergenicity of proteins is a subtle property encoded in their structures.The prediction of allergenicity of novel proteins saves time and resources forsubsequent experimental work. In the host antigen-presenting cells, the allergens areprocessed as antigens by the means of Human Leukocyte Antigens (HLA) class IIproteins. Sometimes, people allergic to a given protein show allergic reaction to adifferent protein, even when the two proteins have different routes of exposure. Thisphenomenon is termed cross-reactivity. Here, we describe a server for allergenicityand cross-reactivity prediction based on the abilities of allergenic proteinsto generate binders to HLA class II proteins. The generated peptides arecompared to HLA binders originating from known allergens. As a result, theserver returns a list of common binders, origin proteins, and species.Different species generate common HLA binders and this determines their cross-reactivity. The server is named AllerScreener and is freely accessible at:http//www.ddg-pharmfac.net/AllerScreener.
关键词：AllerScreener; allergenicity; cross-reactivity; EpiTOP; EpiDOCK; HLA class II.
