摘要:Qinghai-Tibet Plateau is a typical resource-rich but economically backward region in western China, and it is of great urgency to improve human well-being. Combined with previous scholars’ research and the characteristics of Qinghai-Tibet Plateau, this paper constructs an index system of human well-being including four dimensions: income and consumption, means of production, means of subsistence, and resource acquisition ability. Then, it uses generalized matrix method estimations to measure the influence of energy utilization and economic development on human well-being and makes a regression analysis on the influence of energy utilization and economic development on human well-being in various provinces in this region. It is found that per capita GDP and coke utilization promote the well-being of all dimensions, while the urban registered unemployment rate only promotes the well-being of means of subsistence. The utilization of gasoline and natural gas promotes income and consumption and inhibits the means of subsistence and resource acquisition ability, but they have opposite effects on means of production. The impacts of energy utilization and economic development in different provinces on human well-being are different. This study is of great significance to the related research aiming at improving people’s livelihood and promoting regional development.