摘要：SummaryCircadian rhythms regulate adaptive alterations in mammalian physiology and are maximally entrained by the short wavelength blue spectrum; cataracts block the transmission of light, particularly blue light. Cataract surgery is performed with two types of intraocular lenses (IOL): (1) conventional IOL that transmit the entire visible spectrum and (2) blue-light-filtering (BF) IOL that block the short wavelength blue spectrum. We hypothesized that the transmission properties of IOL are associated with long-term survival. This retrospective cohort study of a 15-hospital healthcare system identified 9,108 participants who underwent bilateral cataract surgery; 3,087 were implanted with conventional IOL and 6,021 received BF-IOL. Multivariable Cox proportional hazards models that included severala prioridetermined subgroup and sensitivity analyses yielded estimates supporting that conventional IOL compared with BF-IOL may be associated with significantly reduced risk of long-term death. Confirming these differences and identifying any potential causal mechanisms await the conduct of appropriately controlled prospective translational trials.Graphical abstractDisplay OmittedHighlights•Risk of all-cause mortality in 9,108 patients after bilateral cataract surgery•Comparison of conventional intraocular lenses to blue-light-filtering intraocular lenses•Conventional lenses that transmit the entire visible spectrum may improve survival•Glaucoma patients particularly may benefit from conventional intraocular lensesMedicine; Ophthalmology; Biological Sciences; Neuroscience
