摘要：Trichomoniasis is a public health problem worldwide. Trichomoniasis treatment consists of the use of nitroimidazole derivatives; however, therapeutic ineffectiveness occurs in 5 to 20 % of the cases. Therefore, it is essential to propose new pharmacological agents against this disease. In this work, esters of quinoxaline-7-carboxylate-1,4-di-N-oxide (EQX-NO) were evaluated inin vitroassays as novel trichomonicidal agents. Additionally, anin vitroenzyme assay and molecular docking analysis against triosephosphate isomerase ofTrichomonas vaginalisto confirm their mechanism of action were performed. Ethyl (compound12) andn-propyl (compound37) esters of quinoxaline-7-carboxy-late-1,4-di-N-oxide derivatives showed trichomonicidal activity comparable to nitazoxanide, whereas five methyl (compounds5,15,19,20and22), four isopropyl (compounds28,29,30and34), three ethyl (compounds4,13and23) and onenpropyl (compound35) ester derivatives displayed activity comparable to albendazole. Compounds6and20decreased 100 % of the enzyme activity of recombinant protein triosephosphate isomerase.
