期刊名称：IOP Conference Series: Earth and Environmental Science
印刷版ISSN：1755-1307
电子版ISSN：1755-1315
出版年度：2020
卷号：433
期号：1
DOI：10.1088/1755-1315/433/1/012047
语种：English
出版社：IOP Publishing
摘要：To study the role of BMP signaling pathway in the development of skin tumors, we employed two-stage chemical carcinogenesis protocol on K14-Noggin mice expressing BMP antagonist noggin in the epidermis. A comparative analysis showed an earlier appearance and a significant increase in the number of skin papillomas in K14-Noggin mice compared to the wild-type control (FVB). In contrast to control mice, the transgenic K14-Noggin mice also developed squamous cell carcinoma with local metastasis of malignant cells into the dermis of the skin. The results of this work indicate the tumor suppressive role of BMP signaling pathway in the skin epithelium.
