摘要：SummaryIn contrast to the conventional pulsatile neuromodulation that excites neurons, galvanic or direct current stimulation can excite, inhibit, or sensitize neurons. The vestibular system presents an excellent system for studying galvanic neural interface due to the spontaneously firing afferent activity that needs to be either suppressed or excited to convey head motion sensation. We determine the cellular mechanisms underlying the beneficial properties of galvanic vestibular stimulation (GVS) by creating a computational model of the vestibular end organ that elicits all experimentally observed response characteristics to GVS simultaneously. When GVS was modeled to affect the axon alone, the complete experimental data could not be replicated. We found that if GVS affects hair cell vesicle release and axonal excitability simultaneously, our modeling results matched all experimental observations. We conclude that contrary to the conventional belief that GVS affects only axons, the hair cells are likely also affected by this stimulation paradigm.Graphical abstractDisplay OmittedHighlights•Galvanic vestibular stimulation was shown to evoke naturalistic neural responses•Conventional understanding maintains that it affects only afferent axons•In contrast, our work suggests that it affects both hair cells and afferents•Our work further explains the likely underlying mechanisms of these effectsBiological Sciences; Cellular Neuroscience; Neuroscience;
